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2020

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey@@Sue Ann Costa Clemens@@Shabir A Madhi@@Lily Y Weckx@@Pedro M Folegatti@@Parvinder K Aley@@Brian Angus@@Vicky L Baillie@@Shaun L Barnabas@@Qasim E Bhorat@@Sagida Bibi@@Carmen Briner@@Paola Cicconi@@Andrea M Collins@@Rachel Colin-Jones@@Clare L Cutland@@Thomas C Darton@@Keertan Dheda@@Christopher J A Duncan@@Katherine R W Emary@@Katie J Ewer@@Lee Fairlie@@Saul N Faust@@Shuo Feng@@Daniela M Ferreira@@Adam Finn@@Anna L Goodman@@Catherine M Green@@Christopher A Green@@Paul T Heath@@Catherine Hill@@Helen Hill@@Ian Hirsch@@Susanne H C Hodgson@@Alane Izu@@Susan Jackson@@Daniel Jenkin@@Carina C D Joe@@Simon Kerridge@@Anthonet Koen@@Gaurav Kwatra@@Rajeka Lazarus@@Alison M Lawrie@@Alice Lelliott@@Vincenzo Libri@@Patrick J Lillie@@Raburn Mallory@@Ana V A Mendes@@Eveline P Milan@@Angela M Minassian@@Alastair McGregor@@Hazel Morrison@@Yama F Mujadidi@@Anusha Nana@@Peter J O’Reilly@@Sherman D Padayachee@@Ana Pittella@@Emma Plested@@Katrina M Pollock@@Maheshi N Ramasamy@@Sarah Rhead@@Alexandre V Schwarzbold@@Nisha Singh@@Andrew Smith@@Rinn Song@@Matthew D Snape@@Eduardo Sprinz@@Rebecca K Sutherland@@Richard Tarrant@@Emma C Thomson@@M Estée Török@@Mark Toshner@@David P J Turner@@Johan Vekemans@@Tonya L Villafana@@Marion E E Watson@@Christopher J Williams@@Alexander D Douglas@@Adrian V S Hill@@Teresa Lambe@@Sarah C Gilbert@@Andrew J Pollard@@Marites Aban@@Fatola Abayomi@@Kushala Abeyskera@@Jeremy Aboagye@@Matthew Adam@@Kirsty Adams@@James Adamson@@Yemi A. Adelaja@@Syed Adlou@@Khatija Ahmed@@Yasmeen Akhalwaya@@Saajida Akhalwaya@@Andrew Alcock@@Aabidah Ali@@Elizabeth R. Allen@@Lauren Allen@@Thamires C. D. S. C Almeida@@Mariana P.S. Alves@@Fabio Amorim@@Foteini Andritsou@@Rachel Anslow@@Matthew Appleby@@Edward H. Arbe-Barnes@@Mark P. Ariaans@@Beatriz Arns@@Laiana Arruda@@Gbadebo Awedetan@@Paula Azi@@Lorena Azi@@Gavin Babbage@@Catherine Bailey@@Kenneth F. Baker@@Megan Baker@@Natalie Baker@@Philip Baker@@Lisa Baldwin@@Ioana Baleanu@@Danieli Bandeira@@Anna Bara@@Marcella A.S. Barbosa@@Debbie Barker@@Gavin D. Barlow@@Eleanor Barnes@@Andrew S. Barr@@Jordan R. Barrett@@Jessica Barrett@@Louise Bates@@Alexander Batten@@Kirsten Beadon@@Emily Beales@@Rebecca Beckley@@Sandra Belij-Rammerstorfer@@Jonathan Bell@@Duncan Bellamy@@Nancy Bellei@@Sue Belton@@Adam Berg@@Laura Bermejo@@Eleanor Berrie@@Lisa Berry@@Daniella Berzenyi@@Amy Beveridge@@Kevin R. Bewley@@Helen Bexhell@@Sutika Bhikha@@Asad E. Bhorat@@Zaheda E. Bhorat@@Else Bijker@@Geeta Birch@@Sarah Birch@@Adam Bird@@Olivia Bird@@Karen Bisnauthsing@@Mustapha Bittaye@@Katherine Blackstone@@Luke Blackwell@@Heather Bletchly@@Caitlin L. Blundell@@Susannah R. Blundell@@Pritesh Bodalia@@Bruno C. Boettger@@Emma Bolam@@Elena Boland@@Daan Bormans@@Nicola Borthwick@@Francesca Bowring@@Amy Boyd@@Penny Bradley@@Tanja Brenner@@Phillip Brown@@Claire Brown@@Charlie Brown-O'Sullivan@@Scott Bruce@@Emily Brunt@@Ruaridh Buchan@@William Budd@@Yusuf A. Bulbulia@@Melanie Bull@@Jamie Burbage@@Hassan Burhan@@Aileen Burn@@Karen R. Buttigieg@@Nicholas Byard@@Ingrid Cabera Puig@@Gloria Calderon@@Anna Calvert@@Susana Camara@@Michelangelo Cao@@Federica Cappuccini@@João R. Cardoso@@Melanie Carr@@Miles W. Carroll@@Andrew Carson-Stevens@@Yasmin de M. Carvalho@@José A.M. Carvalho@@Helen R. Casey@@Paul Cashen@@Thais Castro@@Lucia Carratala Castro@@Katrina Cathie@@Ana Cavey@@José Cerbino-Neto@@Jim Chadwick@@David Chapman@@Sue Charlton@@Irina Chelysheva@@Oliver Chester@@Sunder Chita@@Jee-Sun Cho@@Liliana Cifuentes@@Elizabeth Clark@@Matthew Clark@@Andrea Clarke@@Elizabeth A. Clutterbuck@@Sarah L.K. Collins@@Christopher P. Conlon@@Sean Connarty@@Naomi Coombes@@Cushla Cooper@@Rachel Cooper@@Lynne Cornelissen@@Tumena Corrah@@Catherine Cosgrove@@Tony Cox@@Wendy E.M. Crocker@@Sarah Crosbie@@Lorraine Cullen@@Dan Cullen@@Debora R.M.F. Cunha@@Christina Cunningham@@Fiona C. Cuthbertson@@Suzete N. Farias Da Guarda@@Larissa P. da Silva@@Brad E. Damratoski@@Zsofia Danos@@Maria T.D.C. Dantas@@Paula Darroch@@Mehreen S. Datoo@@Chandrabali Datta@@Malika Davids@@Sarah L. Davies@@Hannah Davies@@Elizabeth Davis@@Judith Davis@@John Davis@@Maristela M.D. De Nobrega@@Lis Moreno De Oliveira Kalid@@David Dearlove@@Tesfaye Demissie@@Amisha Desai@@Stefania Di Marco@@Claudio Di Maso@@Maria I.S. Dinelli@@Tanya Dinesh@@Claire Docksey@@Christina Dold@@Tao Dong@@Francesca R. Donnellan@@Tannyth Dos Santos@@Thainá G. dos Santos@@Erika Pachecho Dos Santos@@Naomi Douglas@@Charlotte Downing@@Jonathan Drake@@Rachael Drake-Brockman@@Kimberley Driver@@Ruth Drury@@Susanna J. Dunachie@@Benjamin S. Durham@@Lidiana Dutra@@Nicholas J.W. Easom@@Samual van Eck@@Mandy Edwards@@Nick J. Edwards@@Omar M. El Muhanna@@Sean C. Elias@@Mike Elmore@@Marcus English@@Alisgair Esmail@@Yakub Moosa Essack@@Eoghan Farmer@@Mutjaba Farooq@@Madi Farrar@@Leonard Farrugia@@Beverley Faulkner@@Sofiya Fedosyuk@@Sally Felle@@Shuo Feng@@Carla Ferreira Da Silva@@Samantha Field@@Richard Fisher@@Amy Flaxman@@James Fletcher@@Hazel Fofie@@Henry Fok@@Karen J. Ford@@Jamie Fowler@@Pedro H.A. Fraiman@@Emma Francis@@Marilia M. Franco@@John Frater@@Marilúcia S.M. Freire@@Samantha H. Fry@@Sabrina Fudge@@Julie Furze@@Michelle Fuskova@@Pablo Galian-Rubio@@Eva Galiza@@Harriet Garlant@@Madita Gavrila@@Ailsa Geddes@@Karyna A. Gibbons@@Ciaran Gilbride@@Hardeep Gill@@Sharon Glynn@@Kerry Godwin@@Karishma Gokani@@Ursula Carvalho Goldoni@@Maria Goncalves@@Isabela G.S. Gonzalez@@Jayne Goodwin@@Amina Goondiwala@@Katherine Gordon-Quayle@@Giacomo Gorini@@Janet Grab@@Lara Gracie@@Melanie Greenland@@Nicola Greenwood@@Johann Greffrath@@Marisa M. Groenewald@@Leonardo Grossi@@Gaurav Gupta@@Mark Hackett@@Bassam Hallis@@Mainga Hamaluba@@Elizabeth Hamilton@@Daniel Hammersley@@Aidan T. Hanrath@@Brama Hanumunthadu@@Stephanie A. Harris@@Clair Harris@@Tara Harris@@Thomas D. Harrison@@Daisy Harrison@@Thomas C. Hart@@Birgit Hartnell@@Shadin Hassan@@John Haughney@@Sophia Hawkins@@Jodie Hay@@Ian Head@@John Henry@@Macarena Hermosin Herrera@@David B. Hettle@@Jennifer Hill@@Gina Hodges@@Elizea Horne@@Mimi M. Hou@@Catherine Houlihan@@Elizabeth Howe@@Nicola Howell@@Jonathan Humphreys@@Holly E. Humphries@@Katrina Hurley@@Claire Huson@@Angela Hyder-Wright@@Catherine Hyamns@@Sabina Ikram@@Alka Ishwarbhai@@Monica Ivan@@Poppy Iveson@@Vidyashankara Iyer@@Frederic Jackson@@Jeanne De Jager@@Shameem Jaumdally@@Helen Jeffers@@Natasha Jesudason@@Bryony Jones@@Kathryn Jones@@Elizabeth Jones@@Christopher Jones@@Marianna Rocha Jorge@@Aylin Jose@@Amar Joshi@@Eduardo A.M.S. Júnior@@Joanne Kadziola@@Reshma Kailath@@Faeeza Kana@@Konstantinos Karampatsas@@Mwila Kasanyinga@@Jade Keen@@Elizabeth J. Kelly@@Dearbhla M. Kelly@@Debbie Kelly@@Sarah Kelly@@David Kerr@@Renato de Ávila Kfouri@@Liaquat Khan@@Baktash Khozoee@@Sarah Kidd@@Annabel Killen@@Jasmin Kinch@@Patrick Kinch@@Lloyd D.W. King@@Thomas B. King@@Lucy Kingham@@Paul Klenerman@@Francesca Knapper@@Julian C. Knight@@Daniel Knott@@Stanislava Koleva@@Matilda Lang@@Gail Lang@@Colin W. Larkworthy@@Jessica P.J. Larwood@@Rebecca Law@@Erica M. Lazarus@@Amanda Leach@@Emily A. Lees@@Nana-Marie Lemm@@Alvaro Lessa@@Stephanie Leung@@Yuanyuan Li@@Amelia M. Lias@@Kostas Liatsikos@@Aline Linder@@Samuel Lipworth@@Shuchang Liu@@Xinxue Liu@@Adam Lloyd@@Stephanie Lloyd@@Lisa Loew@@Raquel Lopez Ramon@@Leandro Lora@@Vicki Lowthorpe@@Kleber Luz@@Jonathan C. MacDonald@@Gordon MacGregor@@Meera Madhavan@@David O. Mainwaring@@Edson Makambwa@@Rebecca Makinson@@Mookho Malahleha@@Ross Malamatsho@@Garry Mallett@@Kushal Mansatta@@Takalani Maoko@@Katlego Mapetla@@Natalie G. Marchevsky@@Spyridoula Marinou@@Emma Marlow@@Gabriela N. Marques@@Paula Marriott@@Richard P. Marshall@@Julia L. Marshall@@Flávia J. Martins@@Masebole Masenya@@Mduduzi Masilela@@Shauna K. Masters@@Moncy Mathew@@Hosea Matlebjane@@Kedidimetse Matshidiso@@Olga Mazur@@Andrea Mazzella@@Hugh McCaughan@@Joanne McEwan@@Joanna McGlashan@@Lorna McInroy@@Zoe McIntyre@@Daniela McLenaghan@@Nicky McRobert@@Steve McSwiggan@@Clare Megson@@Savviz Mehdipour@@Wilma Meijs@@Renata N.Á. Mendonça@@Alexander J. Mentzer@@Neginsadat Mirtorabi@@Celia Mitton@@Sibusiso Mnyakeni@@Fiona Moghaddas@@Kgaogelo Molapo@@Mapule Moloi@@Maria Moore@@M. Isabel Moraes-Pinto@@Marni Moran@@Ella Morey@@Róisín Morgans@@Susan Morris@@Sheila Morris@@Helen C. Morris@@Franca Morselli@@Gertraud Morshead@@Richard Morter@@Lynelle Mottal@@Andrew Moultrie@@Nathifa Moya@@Mushiya Mpelembue@@Sibekezelo Msomi@@Yvonne Mugodi@@Ekta Mukhopadhyay@@Jilly Muller@@Alasdair Munro@@Claire Munro@@Sarah Murphy@@Philomena Mweu@@Celia Hatsuko Myasaki@@Gurudutt Naik@@Kush Naker@@Eleni Nastouli@@Abida Nazir@@Bongani Ndlovu@@Fabio Neffa@@Cecilia Njenga@@Helena Noal@@Andrés Noé@@Gabrielle Novaes@@Fay L. Nugent@@Géssika Nunes@@Katie O'Brien@@Daniel O'Connor@@Miranda Odam@@Suzette Oelofse@@Blanche Oguti@@Victoria Olchawski@@Neil J. Oldfield@@Marianne G. Oliveira@@Catarina Oliveira@@Angela Oosthuizen@@Paula O'Reilly@@Piper Osborne@@David R.J. Owen@@Lydia Owen@@Daniel Owens@@Nelly Owino@@Mihaela Pacurar@@Brenda V.B. Paiva@@Edna M.F. Palhares@@Susan Palmer@@Sivapriyai Parkinson@@Helena M.R.T. Parracho@@Karen Parsons@@Dipak Patel@@Bhumika Patel@@Faeezah Patel@@Kelly Patel@@Maia Patrick-Smith@@Ruth O. Payne@@Yanchun Peng@@Elizabeth J. Penn@@Anna Pennington@@Marco Polo Peralta Alvarez@@James Perring@@Nicola Perry@@Rubeshan Perumal@@Sahir Petkar@@Tricia Philip@@Daniel J. Phillips@@Jennifer Phillips@@Mary Kgomotso Phohu@@Lorinda Pickup@@Sonja Pieterse@@Jo Piper@@Dimitra Pipini@@Mary Plank@@Joan Du Plessis@@Samuel Pollard@@Jennifer Pooley@@Anil Pooran@@Ian Poulton@@Claire Powers@@Fernando B. Presa@@David A. Price@@Vivien Price@@Marcelo Primeira@@Pamela C. Proud@@Samuel Provstgaard-Morys@@Sophie Pueschel@@David Pulido@@Sheena Quaid@@Ria Rabara@@Alexandra Radford@@Kajal Radia@@Durga Rajapaska@@Thurkka Rajeswaran@@Alberto San Francisco Ramos@@Fernando Ramos Lopez@@Tommy Rampling@@Jade Rand@@Helen Ratcliffe@@Tom Rawlinson@@David Rea@@Byron Rees@@Jesús Reiné@@Mila Resuello-Dauti@@Emilia Reyes Pabon@@Carla M. Ribiero@@Marivic Ricamara@@Alex Richter@@Neil Ritchie@@Adam J. Ritchie@@Alexander J. Robbins@@Hannah Roberts@@Ryan E. Robinson@@Hannah Robinson@@Talita T. Rocchetti@@Beatriz Pinho Rocha@@Sophie Roche@@Christine Rollier@@Louisa Rose@@Amy L. Ross Russell@@Lindie Rossouw@@Simon Royal@@Indra Rudiansyah@@Sarah Ruiz@@Stephen Saich@@Claudia Sala@@Jessica Sale@@Ahmed M. Salman@@Natalia Salvador@@Stephannie Salvador@@Milla Sampaio@@Annette D. Samson@@Amada Sanchez-Gonzalez@@Helen Sanders@@Katherine Sanders@@Erika Santos@@Mayara F.S. Santos Guerra@@Iman Satti@@Jack E. Saunders@@Caroline Saunders@@Aakifah Sayed@@Ina Schim van der Loeff@@Annina B. Schmid@@Ella Schofield@@Gavin Screaton@@Samiullah Seddiqi@@Rameswara R. Segireddy@@Roberta Senger@@Sonia Serrano@@Rajiv Shah@@Imam Shaik@@Hannah E. Sharpe@@Katherine Sharrocks@@Robert Shaw@@Adam Shea@@Amy Shepherd@@James G. Shepherd@@Farah Shiham@@Emad Sidhom@@Sarah E. Silk@@Antonio Carlos da Silva Moraes@@Gilberto Silva-Junior@@Laura Silva-Reyes@@Anderson D. Silveira@@Mariana B.V. Silveira@@Jaisi Sinha@@Donal T. Skelly@@Daniel C. Smith@@Nick Smith@@Holly E. Smith@@David J. Smith@@Catherine C. Smith@@Airanuédida Soares@@Tiago Soares@@Carla Solórzano@@Guilherme L. Sorio@@Kim Sorley@@Tiffany Sosa-Rodriguez@@Cinthia M.C.D.L. Souza@@Bruno S.D.F. Souza@@Alessandra R. Souza@@Alexandra J. Spencer@@Fernanda Spina@@Louise Spoors@@Lizzie Stafford@@Imogen Stamford@@Igor Starinskij@@Ricardo Stein@@Jill Steven@@Lisa Stockdale@@Lisa V. Stockwell@@Louise H. Strickland@@Arabella C. Stuart@@Ann Sturdy@@Natalina Sutton@@Anna Szigeti@@Abdessamad Tahiri-Alaoui@@Rachel Tanner@@Carol Taoushanis@@Alexander W. Tarr@@Keja Taylor@@Ursula Taylor@@Iona Jennifer Taylor@@Justin Taylor@@Rebecca te Water Naude@@Yrene Themistocleous@@Andreas Themistocleous@@Merin Thomas@@Kelly Thomas@@Tonia M. Thomas@@Asha Thombrayil@@Fawziyah Thompson@@Amber Thompson@@Kevin Thompson@@Ameeka Thompson@@Julia Thomson@@Viv Thornton-Jones@@Patrick J. Tighe@@Lygia Accioly Tinoco@@Gerlynn Tiongson@@Bonolo Tladinyane@@Michele Tomasicchio@@Adriana Tomic@@Susan Tonks@@Nguyen Tran@@Julia Tree@@Gerry Trillana@@Charlotte Trinham@@Rose Trivett@@Adam Truby@@Betty Lebogang Tsheko@@Aadil Turabi@@Richard Turner@@Cheryl Turner@@Marta Ulaszewska@@Benjamin R. Underwood@@Rachel Varughese@@Dennis Verbart@@Marije Verheul@@Iason Vichos@@Taiane Vieira@@Claire S. Waddington@@Laura Walker@@Erica Wallis@@Matthew Wand@@Deborah Warbick@@Theresa Wardell@@George Warimwe@@Sarah C. Warren@@Bridget Watkins@@Ekaterina Watson@@Stewart Webb@@Alice Webb-Bridges@@Angela Webster@@Jessica Welch@@Jeanette Wells@@Alison West@@Caroline White@@Rachel White@@Paul Williams@@Rachel L. Williams@@Rebecca Winslow@@Mark Woodyer@@Andrew T. Worth@@Danny Wright@@Marzena Wroblewska@@Andy Yao@@Rafael Zimmer@@Dalila Zizi@@Peter Zuidewind
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Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK